What other primary cells are used in ADMET studies?
Primary cells derived from lung tissue are preferred for studying ADMET to understand the effect of volatile drugs and nanoparticles on the lungs. Primary cells of the skin are another major type of cells used for ADMET studies.
Primary human keratinocytes and dermal fibroblasts are the common types of cells used for ADMET studies on skin. This is mainly done for cosmetics and gels. Kidneys and the liver are also crucial to the passage of toxic chemicals in the body and therefore, primary cells derived from the kidney and liver also pose special mention when it comes to ADMET studies.
